Viral Disease Networks

Viral perturbations of host networks reflect disease etiology

Viral Perturbations of Host Networks Reflect Disease Etiology

Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viru...

CT 2.1.3 Viral Networks, connecting virus-human interaction networks to population disease patterns

Introduction To discover the underlying principles that translate genomic information to observed phenotypes (e.g., diseases) the study of global properties of cellular networks is essential. Any perturbation to the network, originated by a virus or drug, impacts not just the locally targeted subnetwork but spreads through out the network. This global cascading damage spreading in cellular netw...

Viral Disease in Hematology.

As part of the international outreach of the American Society of Hematology, this review addresses some aspects of the genetics, biology, epidemiology, and clinical relevance of viruses that cause a variety of hematopoietic disorders in human populations. The viruses described here have a different pattern of geographical distribution, and the disease manifestations may vary according to enviro...

PPARs in Viral Disease

This special issue of PPAR Research contains an exciting array of valuable reviews examining the relationship between PPARs and various viral infections, varying from HIV to HCV and HBV. This assembly of reviews includes a group of three complimentary reviews addressing different facets of the cross-talk between HIV infection and antiretroviral treatment as well as the potential beneficial role...